Casting de Vainqueur du destin
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Gary CooperHenry Louis 'Lou' Gehrig
Teresa WrightEleanor Twitchell
Babe RuthBabe Ruth
Walter BrennanSam Blake
Dan DuryeaHank Hanneman
Elsa JanssenChristina 'Mom' Gehrig
Ludwig StösselHenry 'Pop' Gehrig
Virginia GilmoreMyra Tinsley
Bill DickeyBill Dickey
Ernie AdamsMiller Huggins
Pierre WatkinMr. Twitchell
Harry HarveyJoe McCarthy- Bob MeuselRobert W. Meusel (as Robert W. Meusel)
- Mark KoenigMark Koenig
- Bill SternBill Stern
Addison RichardsCoach
Hardie AlbrightVan Tuyl
Edward FieldingClinic Doctor
George LesseyMayor of New Rochelle
Edgar BarrierHospital Doctor
Douglas CroftLou Gehrig as a Boy- Gene CollinsBilly (Age 8)
David HoltBilly (Age 17)
VelozSpecialty Dancer (as Veloz and Yolanda)
YolandaSpecialty Dancer (as Veloz and Yolanda)- Ed AgrestiBarber (uncredited)
- Ernie AlexanderBellhop with Flowers (uncredited)
Hooper AtchleyLathered Man in Barber Shop (uncredited)
Edwin AugustRestaurant Patron (uncredited)- Bettye AveryNightclub Singer (uncredited)
- Becky BohanonLittle Girl (uncredited)
Lynton BrentPhotographer in Hospital (uncredited)- Roy BrentYankee Ballplayer (uncredited)
Betty BrewerLittle Girl (uncredited)
Don BrodieGirl Show Barker (uncredited)
Charles CanePlumber (uncredited)- Jack CarrPlumber (uncredited)
- Burr CaruthVillage Storekeeper (uncredited)
Eddy ChandlerMotorcycle Cop #2 (uncredited)
Lane ChandlerMark - Player in Locker Room (uncredited)- Bill ChaneyNewsboy (uncredited)
- Jack ChapinPhotographer (uncredited)
Janet ChapmanTessie (uncredited)
Spencer ChartersMr. Larsen (uncredited)- Porter ChaseWeight Guesser (uncredited)
Dane ClarkFraternity Boy (uncredited)
Heinie ConklinWallpaper Hanger (uncredited)- Hal CookeMan in Cab (uncredited)
Clancy CooperMotorcycle Cop #1 (uncredited)- John DaheimReporter in Hospital (uncredited)
- Eva DennisonMrs. Worthington (uncredited)
Lester DorrDisappointed Fan #1 (uncredited)- Peter Du ReyPhotographer in Hospital (uncredited)
- Lorna DunnClinic Nurse (uncredited)
- Jim FarleySpectator (uncredited)
Frank FaylenYankee Third Base Coach (uncredited)
Walter FennerDentist (uncredited)
Pat FlahertyYankee Ballplayer (uncredited)
Rosina GalliMrs. Fabrini (uncredited)
Vaughan GlaserDoctor in Gehrig Home (uncredited)- Dick GordonRadio Listener (uncredited)
Mary GordonMaid (uncredited)- Herschel GrahamSpectator (uncredited)
George GuhlSecond Paper Hanger (uncredited)
Eddie HallReporter in Hospital Room (uncredited)
Harry HaydenDepartment Store Manager (uncredited)
Vinton HayworthFraternity Boy (uncredited)- Oscar 'Dutch' HendrianFurniture Mover (uncredited)
- John HiestandAnnouncer (uncredited)
Earle HodginsBottle Game Operator (uncredited)
Fay HoldernessSpectator (uncredited)
John InceMan in Box Seat (uncredited)
Mitchell IngrahamBarber (uncredited)
Charles IrwinCarnival Batting Game Operator (uncredited)- Jack IrwinPhotographer in Hospital (uncredited)
- Sheldon JettSportsman at Ballgame (uncredited)
- Payne B. JohnsonBoy in Ball Park (uncredited)
John KelloggFraternity Boy (uncredited)
Colin KennyYankee Player on Train (uncredited)
Donald KerrPhotographer (uncredited)- Richard KiplingBroker (uncredited)
- Pat LaneWheel of Chance Barker (uncredited)
- Larry LawsonBarker (uncredited)
Rex LeaseSpectator (uncredited)
Theodore LorchNeighbor Leaning Through Window (uncredited)- Frank LymanFraternity Boy (uncredited)
Wilbur MackMan Outside Yankee Stadium (uncredited)- Dave ManleyMayor Fiorello LaGuardia (uncredited)
- Maurice MarksPlayer (uncredited)
- Francisco MaránRathskeller Headwaiter (uncredited)
- John C. McCallumMinor Role (uncredited)
- Ralph McCulloughReporter in Hospital (uncredited)
- George McDonaldWally Pipp (uncredited)
Matt McHughStrength Machine Operator (uncredited)- James McNamaraRathskeller Manager (uncredited)
Wilmuth MerkylSpectator (uncredited)
Howard M. MitchellSportsman at Ballgame (uncredited)- Irving MitchellHeadwaiter (uncredited)
- Pat MoriarityPoliceman in 1915 (uncredited)
Tom NealFraternity Boy (uncredited)
Ray NobleOrchestra Leader (uncredited)- Patsy O'ByrneScrubwoman (uncredited)
George Offerman, Jr.Freshman (uncredited)- John B. OldReporter (uncredited)
Garry OwenScorecard Vendor (uncredited)
Sarah PaddenMrs. Roberts (uncredited)
Emory ParnellChicago Policeman O'Doul (uncredited)
Edward Peil Sr.Policeman (uncredited)- Tom QuinnReporter in Hospital (uncredited)
Cyril RingPhotographer (uncredited)- Henry RoquemoreDisappointed Fan #2 (uncredited)
Art RowlandsTelephone Man (uncredited)
William RoyJoe Fabrini (uncredited)- Rip RussellLaddie (uncredited)
- Francis SaylesCab Driver (uncredited)
Anita Sharp-BolsterSasha's Mother (uncredited)
C. Montague ShawMr. Worthington (uncredited)- Jack SheaHammond (uncredited)
John SheehanFirst Paper Hanger (uncredited)
Jack StewartEd Barrow (uncredited)- Brick SullivanPoliceman (uncredited)
Ben TaggartConductor (uncredited)
Walter TetleyCake Delivery Boy (uncredited)- Jimmy ValentineSasha - Boy Playing Baseball (uncredited)
- Gohr Van VleckFurniture Mover (uncredited)
Dorothy VaughanEleanor's Landlady (uncredited)
Dorothy VernonFamily Friend (uncredited)
Malcolm WaiteBig Strength Machine Contestant (uncredited)
James WesterfieldSpectator (uncredited)
Guy WilkersonSportsman at Ballgame (uncredited)- Max WillenzMr. Colletti (uncredited)
- Buddy WilliamsBootblack (uncredited)
Charles WilliamsLittle Strength Machine Contestant (uncredited)- Robert WinklerMurphy (uncredited)
- Allen WoodFreshman (uncredited)
Dick GordonRadio Listener (uncredited)- Charles FlynnFraternity Boy (uncredited)
- Anthony WaltersMerril (uncredited)