Casting de Big trouble
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Tim AllenEliot Arnold
Rene RussoAnna Herk
Ben FosterMatt Arnold
Jason LeePuggy
Stanley TucciArthur Herk
Dennis FarinaHenry Desalvo
Zooey DeschanelJenny Herk
Janeane GarofaloMonica Romero
Sofía VergaraNina
Tom SizemoreSnake
Johnny KnoxvilleEddie
Omar EppsSeitz
Heavy DGreer
Patrick WarburtonWalter Kramitz
Jack KehlerLeonard
DJ QuallsAndrew
Michael McShaneBruce
Andy RichterJack/Ralph Pendick
Daniel LondonJohn
Cullen DouglasCaptain Justin Hobart
Flip SchultzCo-Pilot Jan Vigushin- Patrick MicklerCigar Buddy
- Gerald OwensCigar Buddy
- Mitchell CarreyCigar Buddy
- Nathalie LatronicoHeather Weintraub
Jonathan KasdanJack Pendick Trainee
Ian MariolesEditorial Assistant- Philip NolenDeeber
David KoeppAnnoyed Sports Radio Host (voice)
Barry SonnenfeldConfused Sports Radio Call In (voice)
Jay RasumnyCourier #1- Ruben GomezCourier #2
Antoni CoroneWilliam Spaulding
Siobhan Fallon HoganFly by Air Ticket Agent- Kava StewartsonSour Airport Security
Gloria LainoAirport X-Ray Operator
Carmen LópezAirport Stern Security Woman- Mark SalemFly By Air Baggage Handler
- Renato CampilongoGang Leader
Marc MacaulayArch Ridley
James Martin KellyGeo Salesman- Dave CoreyCellmate Dwight
- Selma CipesRetiree #1
Sid RaymondRetiree #2
Jody WilsonRetiree #3- Maurice AlveyRetiree #4
- Mia FinneganAerobics Announcer (voice)
- Eric GellerAerobics Announcer (voice)
- Paul BarthAirline Pilot
Martha StewartHerself
Deborah Smith FordBag Lady (uncredited)
