Casting de Rubberhead
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Sarah SilvermanSelf
Nathan BarnattHomeless Man (segment "Lisa")
Lauren LapkusGirl 5 (segment "Lisa")
John C. ReillyFather (segment "Ham")
Laura SilvermanSelf (segment "Knickers")
Seth RogenOfficer Durand (segment "Knickers")
Jade Catta-PretaMother (segment "Lisa")
Natasha LeggeroGirl 2 (segment "Lisa")- Shelby FeroGirl 1 (segment "Lisa")
Nathan FielderSelf (segment "Retro Video Arcade")- David Dineen-PorterSelf (segment "Retro Video Arcade")
Kyle DunniganSelf
Michael Daniel CassadySelf (segment "Lisa")
Brett GelmanSelf
Emily Maya MillsGirl 6 (segment "Lisa")
Nick RutherfordFather (segment "Lisa")
Rob SchrabSelf
Paul RustSelf (segment "Lisa")- Stoney SharpSelf
Armen WeitzmanMailman
Kulap VilaysackGirl 3 (segment "Lisa")
Eric WareheimSelf- Harris WittelsScientist 1 (segment "CCDF")
Charlyne YiSelf
Tig NotaroGirl 4 (segment "Lisa")
Todd GlassSelf
Grace HelbigBride 5 (segment "Absorption")
2 ChainzSelf (segment "Absorption")
Casey Ford AlexanderBad Guy 2 (segment "CCDF")- Jack BornoffTomato Man (segment "Ham")
- Hailey BoyleCashier (segment "Knickers")
- Aaron ChrenenCooper (segment "Ginger Orphan Playhouse") (voice)
- Larry A. DaviesLloyd (segment "Absorption")
Greg Davis Jr.Groom 2 (segment "Absorption")- Donna DuBainMadame Trinkett (segment "Ginger Orphan Playhouse") (voice)
Trevor EysterBad Guy 1 (segment "CCDF")- Malinda FarringtonMalinda (segment "Ham")
Kate FreundProstitute (segment "CCDF")- David GarciaBad Guy 3 (segment "CCDF")
- Cyrus GhahremaniSelf
Hannah HartBride 4 (segment "Absorption")- Deloris HeardCustomer (segment "Knickers")
- Pamela ImmelPamela (segment "Ham")
- Zack KennedyBand Member 4 (segment "Absorption")
Keegan-Michael KeySelf (segment "Absorption")- Ben LepleyVacuum Salesman (segment "Ginger Orphan Playhouse") (voice)
- Catherine LydonCashier (segment "Ham")
Rasika MathurBride 3 (segment "Absorption")
Kyle PacekSon (segment "Ham")
Sandeep ParikhGroom 3 (segment "Absorption")
Jordan PeeleSelf (segment "Absorption")
Issa RaeBride 2 (segment "Absorption")- Ron RansenBand Member 1 (segment "Absorption")
- Mike RelmSelf
Willy RobertsTaco Truck Worker (segment "CCDF")- Chase StewartSon (segment "Lisa")
Mark TaorminoBand Member 2 (segment "Absorption")- Brittani TaylorBride 1 (segment "Absorption")
- Aono TetsujiBad Guy 4 (segment "CCDF")
- James TrentonJames (segment "Ham")
Jack ValeGroom 1 (segment "Absorption")