Casting de La Perle des Borgia
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Basil RathboneSherlock Holmes
Nigel BruceDr. John Watson
Dennis HoeyInspector Lestrade
Evelyn AnkersNaomi Drake
Miles ManderGiles Conover
Ian WolfeAmos Hodder- Charles FrancisFrancis Digby, curator
Holmes HerbertJames Goodram, courier
Richard AherneMuseum Guard Bates
Mary GordonMrs. Hudson
Rondo HattonThe Hoxton Creeper
Harry CordingGeorge Gelder (uncredited)
Billy BevanConstable With Food Tray (uncredited)
Leyland HodgsonCustoms Officer (uncredited)- Eric WiltonChauffeur (uncredited)
Lillian BronsonMaj. Harker's Housekeeper (uncredited)