Casting de 2010 : L'Année du premier contact
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Roy ScheiderDr. Heywood Floyd
John LithgowDr. Walter Curnow
Helen MirrenTanya Kirbuk
Bob BalabanDr. R. Chandra
Keir DulleaDr. David Bowman
Douglas RainHAL 9000 (voice)
Madolyn Smith OsborneCaroline Floyd
Савелий КрамаровDr. Vladimir Rudenko
Taliesin JaffeChristopher Floyd
James McEachinVictor Milson
Mary Jo DeschanelBetty Fernandez
Elya BaskinMaxim Brailovsky
Dana ElcarDimitri Moisevitch
Oleg RudnikDr. Vasili Orlov
Natasha ShneiderIrina Yakunina
Vladimir SkomarovskyYuri Svetlanov- Victor SteinbachNikolaj Ternovsky
Candice BergenSAL 9000 (voice)- Gene McGarrCommercial Announcer
Herta WareJessie Bowman
Jan TřískaAlexander Kovalev- Larry CarrollAnchorman on TV
- Cheryl CarterNurse
- Ron RecasnerHospital Neurosurgeon
Robert LesserDr. Hirsch
Delana MichaelsCommercial Announcer
Arthur C. ClarkeMan on Park Bench (uncredited)