Casting de Je suis une légende
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Will SmithRobert Neville
Alice BragaAnna Montez
Charlie TahanEthan
Dash MihokAlpha Male
Salli Richardson-WhitfieldZoe Neville
Willow SmithMarley Neville
Emma ThompsonDr. Alice Krippin
Darrell FosterMike - Military Escort
Joanna NumataAlpha Female- Samuel GlenMilitary Driver - Jay
- Pedro MojicaSergeant
Marin IrelandWoman Evacuee
Alexander DiPersiaMale Evacuee
April GraceTV Personality
James McCauleyMale Evacuee- Anthony C. MazzaEvacuation Cop
- Steve CirbusMilitary Police
- Calista HillLittle Girl Evacuee
- Gabriella HillLittle Girl Evacuee
- Madeline HillLittle Girl Evacuee
- Adhi SharmaMilitary Scanning Tech
- Tyree Michael SimpsonEvacuation Cop #2
- Blake LangeCoast Guard Ground Crew
Abraham SparrowMale Evacuee #3
Pat FraleyPresident (voice)
Caitlin McHughSpecial Blond Model- Deborah CollinsCivilian
Mike PattonCreatures (voice)- Katherine BrookInfected
Vince CuponeInfected- Lynna DavisInfected
- Anika EllisInfected
John GradyInfected- Moses Harris Jr.Infected
- Kennis HawkinsInfected
Marc InnissInfected- Eric JenkinsInfected
Reed KellyInfected- Grasan KingsberryInfected
Drew LearyInfected- Asa LiebmannInfected
- Deborah LohseInfected
- Jon-Paul MateoInfected
- Ian MclaughlinInfected
- Luke MillerInfected
Courtney MunchInfected
Kimberly Shannon MurphyInfected
Okwui OkpokwasiliInfected- Erin OwenInfected
Victor PaguiaInfected
Paradox PollackInfected- Will RawlsInfected
- William SchultzInfected
- Hollie K. SeidelInfected
- Hannah SimInfected
- Eric SpearInfected
Mark StegerInfected- Charlie SuttonInfected
- David Hamilton ThomsonInfected
- Anthony VincentInfected
Greg WattkisInfected
Raul TorresMale Evacuee (uncredited)