Casting de Bone Collector
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Denzel WashingtonLincoln Rhyme
Angelina JolieAmelia Donaghy
Queen LatifahThelma
Michael RookerCaptain Howard Cheney
Michael McGloneDetective Kenny Solomon
Luis GuzmánEddie Ortiz
Leland OrserRichard Thompson
John Benjamin HickeyDr. Barry Lehman
Bobby CannavaleSteve, Amelia's Boyfriend
Ed O'NeillDetective Paulie Sellitto
Richard ZemanLieutenant Carl Hanson
Olivia BirkelundLindsay Rubin
Gary SwansonAlan Rubin- James BulleitTrain Engineer
Frank FontaineGrandfather
Zena GreyGranddaughter
Desmond CampbellTaxi Inspector
Peter Michael DillonHomicide Detective
Ted WhittallOrtiz's Assistant
Andy BradshawUniform Cop
Steve AdamsGas Worker- Christian VelizYoung Boy
- Mercedes GómezOrtiz's Mother
- Mary C. HammettGirlfriend in Nightclub
- Amanda GayGirl in Nightclub
Larry DayGas Worker- Burke LawrencePolice Instructor
Terry SimpsonCop in Apartment
Eric DavisCop in Apartment
Arthur HoldenBookstore Clerk
Yahsmin DaviaultRhyme's Sister- Keenan MacWilliamRhyme's Niece
David WarshofskyAmelia's Partner
Mateo GómezHot Dog Vendor- Jonathan StarkMale Detective
Fulvio CecereForensics Expert- Hal ShermanFingerprint Cop
Russell YuenForensics Worker- Jean-Marc BissonRescue Worker
- Christopher BregmanRescue Worker
- Sonya BiddleNurse