Casting de Gridlock'd
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Tupac ShakurEzekiel 'Spoon' Whitmore
Tim RothAlexander 'Stretch' Rawland
Thandiwe NewtonBarbara 'Cookie' Cook
Charles FleischerMr. Woodson
Howard HessemanBlind Man
Vondie Curtis-HallD-Reper
John SaylesCop #1
Lucy LiuCee-cee
Bokeem WoodbineMud (uncredited)
Kasi LemmonsMadonna
Tom TowlesD-Reper's Henchman