Casting de Dara O Briain's Science Club
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Dara Ó BriainHimself - Presenter (12 ep.)
Mark MiodownikHimself - Presenter (12 ep.)
Helen CzerskiHerself - Presenter (12 ep.)- Alok JhaHimself - Presenter (12 ep.)
- Tali SharotHerself - Presenter (6 ep.)
Ed ByrneHimself (1 ep.)
Marcus BrigstockeHimself (1 ep.)
Janna LevinHerself (1 ep.)
Mark SteelHimself (1 ep.)
Josh WiddicombeHimself (1 ep.)
Jessica HynesHerself (1 ep.)- Uta FrithHerself (1 ep.)
James MayHimself (1 ep.)- Noel SharkeyHimself (1 ep.)
- Bruce HoodHimself (1 ep.)
- Emma TeelingHerself (1 ep.)
- Max TegmarkHimself (1 ep.)
- Hilary GeogheganHerself (1 ep.)
- James LoganHimself (1 ep.)
- Molly CrockettHerself (1 ep.)
Michio KakuHimself (1 ep.)- Sally DaviesHerself (1 ep.)
- Jo DunkleyHerself (1 ep.)
- Ian HendersonHimself (1 ep.)
- Molly StevensHerself (1 ep.)