Casting de Bill Nye sauve le monde
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Bill NyeSelf - Host (25 ep.)
Derek MullerSelf - Correspondent (5 ep.)
Karlie KlossSelf - Correspondent (3 ep.)- Nazeem HussainHimself - Correspondent (2 ep.)
- Joanna HausmannSelf - Correspondent (2 ep.)
Emily CalandrelliHerself - Correspondent (2 ep.)
Zach BraffSelf (1 ep.)
DesiignerSelf (1 ep.)
Tracy MannHerself - Panelist (1 ep.)
Sara BenincasaHerself - Panelist (1 ep.)- Jennifer WiderstromHerself - Panelist (1 ep.)
Martin StarrDoug the Caveman (1 ep.)
Lauren AshKale (1 ep.)
Jeff DyeEggplant (1 ep.)
Andi OshoBread (1 ep.)
Heather McDonaldBeef (1 ep.)
Aubrey Anderson-EmmonsThe Director (1 ep.)- Robb FraleyHimself - Panelist (1 ep.)
- Fred GouldHimself - Panelist (1 ep.)
- Julie KennyeHerself - Panelist (1 ep.)
- Katrina KarkazisHerself - Panelist (1 ep.)
- Jeffrey McCune Jr.Himself - Panelist (1 ep.)
Solomon GeorgioHimself - Panelist (1 ep.)
Rachel BloomHerself - Special Guest (1 ep.)
Todd BarryVanilla (voice) (1 ep.)
Sandra BernhardMint Choc Chip (voice) (1 ep.)
Matt LucasSalted Caramel (voice) (1 ep.)
Mario CantoneStrawberry (voice) (1 ep.)
Margaret ChoPistachio (voice) (1 ep.)
Cameron EspositoChocolate (voice) (1 ep.)- Prashanth VenkataramanujamCookies & Cream (voice) (1 ep.)
- Nicole GoDJ Seahorse (1 ep.)
- Ryan CaloSelf - Panelist (1 ep.)
- Xeji JardinSelf - Panelist (1 ep.)
- Subbarao KambhampatiSelf - Panelist (1 ep.)
Neil deGrasse TysonSelf - Voice of Coffee Maker (1 ep.)- Cece PleasantsSelf - Voice of Wilhelmina (1 ep.)
- Sanden TottenSelf - Voice of Refrigerator (1 ep.)
- Salim ShaikhSelf (1 ep.)
- Margaret MitchellSelf (1 ep.)
- Prof. Mark JacobsonSelf - Panelist (1 ep.)
- Richard MartinSelf - Panelist (1 ep.)
Taryn O'NeillSelf - Panelist (1 ep.)
Steve AokiSelf (1 ep.)- Prashanth VenkataramanujamSelf (1 ep.)
- Chris BeedieSelf - Panelist (1 ep.)
Cara Santa MariaSelf - Panelist (1 ep.)- Donald SchultzSelf - Panelist (1 ep.)
Alton BrownHimself (1 ep.)- Hunter PenceHimself (1 ep.)
Randy CoutureTardigrade (1 ep.)- Marcus LindsayTardigrade Victim (1 ep.)
- Andy RossiTardigrade Victim (1 ep.)
- Moogega CooperHerself - Panelist (1 ep.)
Hakeem Muata OluseyiHimself - Panelist (1 ep.)
Wil WheatonHimself - Panelist (1 ep.)- Rachel BloomMartian (1 ep.)
- Lanre FalusiHerself - Panelist (1 ep.)
- Kristen OmearaHerself - Panelist (1 ep.)
- Jennifer ReichHerself - Panelist (1 ep.)
Diedrich BaderSmallpox (1 ep.)
Jim O'HeirRabies (1 ep.)
John O'HurleyInfluenza (1 ep.)- Prashanth VenkataramanujamCasting Director (1 ep.)
George WendtPolio (1 ep.)- Cece PleasantsHPV (1 ep.)
- Sanden TottenEbola (1 ep.)
- Hilarie CashHerself - Panelist (1 ep.)
- Shawn GreenHimself - Panelist (1 ep.)
- Jonna MaeHerself - Panelist (1 ep.)
Gustavo SorolaRooster Teeth (1 ep.)
Geoff RamseyRooster Teeth (1 ep.)
Tim GunnHimself (1 ep.)- Camille HammondHerself - Panelist (1 ep.)
- Leslie HinksonHerself - Panelist (1 ep.)
- Paul KnoepflerHimself - Panelist (1 ep.)
- Nerys BenfieldHerself - Panelist (1 ep.)
- Travis RiederHimself - Panelist (1 ep.)
- Rachel SnowHerself - Panelist (1 ep.)